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Contraindicated. Cobicistat is actually a CYP3A4 inhibitor; contraindicated with CYP3A4 substrates for which elevated plasma concentrations are associated with serious and/or lifetime-threatening gatherings.Watch Intently (one)crofelemer boosts amounts of ergotamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Cr